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The role of membrane-associated adaptors in T cell receptor signalling.

Publication ,  Journal Article
Zhang, W; Samelson, LE
Published in: Semin Immunol
February 2000

Engagement of the T cell receptor leads to activation of several tyrosine kinases and phosphorylation of many intracellular proteins. This is followed by Ca2+ mobilization and activation of multiple biochemical pathways, including the Ras/MAPK cascade, and several downstream serine/threonine kinases. Membrane-associated adaptor proteins play an important role in T cell activation by coupling TCR ligation at the membrane to distal signalling cascades. Several new membrane associated adaptors have been identified in recent years. LAT (linker for activation of T cells) is an adaptor molecule, which following its phosphorylation associates with Grb2, Gads, PLC-gamma 1, and other signalling molecules. The functional importance of this molecule has been demonstrated by the study of LAT-deficient cell lines and LAT-deficient mice. Two other recently identified adaptor proteins, TRIM (T cell receptor interacting molecule) and SIT (SHP2-interacting transmembrane adaptor protein), which constitutively associate with several surface molecules, bind to PI3K and SHP2, respectively, after T cell activation and might also function in the TCR signalling pathway.

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Published In

Semin Immunol

DOI

ISSN

1044-5323

Publication Date

February 2000

Volume

12

Issue

1

Start / End Page

35 / 41

Location

England

Related Subject Headings

  • Type C Phospholipases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Antigen, T-Cell
  • Proteins
  • Phosphoproteins
  • Phospholipase C gamma
  • Membrane Proteins
  • Lymphocyte Activation
 

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Zhang, W., & Samelson, L. E. (2000). The role of membrane-associated adaptors in T cell receptor signalling. Semin Immunol, 12(1), 35–41. https://doi.org/10.1006/smim.2000.0205
Zhang, W., and L. E. Samelson. “The role of membrane-associated adaptors in T cell receptor signalling.Semin Immunol 12, no. 1 (February 2000): 35–41. https://doi.org/10.1006/smim.2000.0205.
Zhang W, Samelson LE. The role of membrane-associated adaptors in T cell receptor signalling. Semin Immunol. 2000 Feb;12(1):35–41.
Zhang, W., and L. E. Samelson. “The role of membrane-associated adaptors in T cell receptor signalling.Semin Immunol, vol. 12, no. 1, Feb. 2000, pp. 35–41. Pubmed, doi:10.1006/smim.2000.0205.
Zhang W, Samelson LE. The role of membrane-associated adaptors in T cell receptor signalling. Semin Immunol. 2000 Feb;12(1):35–41.
Journal cover image

Published In

Semin Immunol

DOI

ISSN

1044-5323

Publication Date

February 2000

Volume

12

Issue

1

Start / End Page

35 / 41

Location

England

Related Subject Headings

  • Type C Phospholipases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Antigen, T-Cell
  • Proteins
  • Phosphoproteins
  • Phospholipase C gamma
  • Membrane Proteins
  • Lymphocyte Activation