The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.
Publication
, Journal Article
Young, AC; Zhang, W; Sacchettini, JC; Nathenson, SG
Published in: Cell
January 14, 1994
Solution at 2.4 A resolution of the structure of H-2Db with the influenza virus peptide NP366-374 (ASNEN-METM) and comparison with the H-2Kb-VSV (RGY-VYQGL) structure allow description of the molecular details of MHC class I peptide binding interactions for mice of the H-2b haplotype, revealing a strategy that maximizes the repertoire of peptides than can be presented. The H-2Db cleft has a mouse-specific hydrophobic ridge that causes a compensatory arch in the backbone of the peptide, exposing the arch residues to TCR contact and requiring the peptide to be at least 9 residues. This ridge occurs in about 40% of the known murine D and L allelic molecules, classifying them as a structural subgroup.
Duke Scholars
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
January 14, 1994
Volume
76
Issue
1
Start / End Page
39 / 50
Location
United States
Related Subject Headings
- X-Ray Diffraction
- Recombinant Proteins
- Receptors, Antigen, T-Cell
- Protein Structure, Secondary
- Protein Conformation
- Polymerase Chain Reaction
- Oligodeoxyribonucleotides
- Molecular Sequence Data
- Models, Molecular
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Young, A. C., Zhang, W., Sacchettini, J. C., & Nathenson, S. G. (1994). The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell, 76(1), 39–50. https://doi.org/10.1016/0092-8674(94)90171-6
Young, A. C., W. Zhang, J. C. Sacchettini, and S. G. Nathenson. “The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.” Cell 76, no. 1 (January 14, 1994): 39–50. https://doi.org/10.1016/0092-8674(94)90171-6.
Young AC, Zhang W, Sacchettini JC, Nathenson SG. The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell. 1994 Jan 14;76(1):39–50.
Young, A. C., et al. “The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.” Cell, vol. 76, no. 1, Jan. 1994, pp. 39–50. Pubmed, doi:10.1016/0092-8674(94)90171-6.
Young AC, Zhang W, Sacchettini JC, Nathenson SG. The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell. 1994 Jan 14;76(1):39–50.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
January 14, 1994
Volume
76
Issue
1
Start / End Page
39 / 50
Location
United States
Related Subject Headings
- X-Ray Diffraction
- Recombinant Proteins
- Receptors, Antigen, T-Cell
- Protein Structure, Secondary
- Protein Conformation
- Polymerase Chain Reaction
- Oligodeoxyribonucleotides
- Molecular Sequence Data
- Models, Molecular
- Mice