LAB: a new membrane-associated adaptor molecule in B cell activation.

Journal Article (Journal Article)

The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.

Full Text

Duke Authors

Cited Authors

  • Janssen, E; Zhu, M; Zhang, W; Koonpaew, S; Zhang, W

Published Date

  • February 2003

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 117 - 123

PubMed ID

  • 12514734

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni882


  • eng

Conference Location

  • United States