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Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.

Publication ,  Journal Article
Janssen, E; Zhu, M; Craven, B; Zhang, W
Published in: J Immunol
June 1, 2004

Adaptor proteins have important functions in coupling stimulation through immunoreceptors with downstream events. The adaptor linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) is expressed in various immune cell types and has a similar domain structure as linker for activation of T cells (LAT). In this study we generated a LAB transgenic mouse to compare the functional differences between LAB and LAT. A LAB transgene expressed in LAT-deficient T cells was able to restore T cell development. However, these mice developed severe organomegaly with disorganized lymphoid tissues. Lymphocytes from these transgenic mice were hyperactivated, and T cells produced large amounts of type II cytokines. In addition, these activities appeared to be uncoupled from the TCR. An examination of the signaling capabilities of these T cells revealed that LAB resembled a LAT molecule unable to bind phospholipase C-gamma1.

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Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

June 1, 2004

Volume

172

Issue

11

Start / End Page

6810 / 6819

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Phosphoproteins
  • Phospholipase C gamma
  • Mice, Transgenic
  • Mice
  • Membrane Proteins
  • Lymphocyte Activation
  • Jurkat Cells
 

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Janssen, E., Zhu, M., Craven, B., & Zhang, W. (2004). Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. J Immunol, 172(11), 6810–6819. https://doi.org/10.4049/jimmunol.172.11.6810
Janssen, Erin, Minghua Zhu, Brandon Craven, and Weiguo Zhang. “Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.J Immunol 172, no. 11 (June 1, 2004): 6810–19. https://doi.org/10.4049/jimmunol.172.11.6810.
Janssen, Erin, et al. “Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.J Immunol, vol. 172, no. 11, June 2004, pp. 6810–19. Pubmed, doi:10.4049/jimmunol.172.11.6810.

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

June 1, 2004

Volume

172

Issue

11

Start / End Page

6810 / 6819

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Phosphoproteins
  • Phospholipase C gamma
  • Mice, Transgenic
  • Mice
  • Membrane Proteins
  • Lymphocyte Activation
  • Jurkat Cells