Adaptor proteins in lymphocyte activation.


Journal Article (Review)

Adaptor proteins are unique, as they contain modular domains and lack intrinsic enzymatic activity. These proteins are scaffolds for the organization of macromolecular complexes and they recruit other proteins for correct localization during molecular signal transduction. Numerous recent advances have been made through the elucidation of new adaptor proteins and the recognition of novel functions for previously identified molecules. In addition, the roles of adaptors in both the positive and negative regulation of lymphocyte activation have been further clarified.

Full Text

Duke Authors

Cited Authors

  • Janssen, E; Zhang, W

Published Date

  • June 2003

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 269 - 276

PubMed ID

  • 12787751

Pubmed Central ID

  • 12787751

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/s0952-7915(03)00044-x


  • eng

Conference Location

  • England