The force-interval relationship of the left ventricle.


Journal Article

We have carried out a quantitative analysis of the force-interval relationship of the human left ventricle and compared it to previous studies done in both intact subjects as well as isolated muscle. The characteristics of the force-interval relationship of the normal patient resembed those of normal isolated mammalian muscle (except when exposed to high levels of catecholamines). The relationship in group 2 (patients with increased left ventricular dimensions and normal pressure indices) resembled those obtained from isolated muscles from hypertrophied hearts. The relationship from group 3 (patients with increased left ventricular EDDs and depressed pressure indices, two of whom were in clinical heart failure) resumbled those induced in normal muscles exposed to high levels of catecholamines, and those obtained from experimentally induced heart failure. The force-interval relationships of the four patients who fell into the third group were strikingly different from the other groups. This suggests that the force-interval relationship may be useful to describe changes in the inotropic state of the patient's heart.

Full Text

Cited Authors

  • Anderson, PA; Manring, A; Serwer, GA; Benson, DW; Edwards, SB; Armstrong, BE; Sterba, RJ; Floyd, RD

Published Date

  • August 1, 1979

Published In

Volume / Issue

  • 60 / 2

Start / End Page

  • 334 - 348

PubMed ID

  • 87282

Pubmed Central ID

  • 87282

Electronic International Standard Serial Number (EISSN)

  • 1524-4539

International Standard Serial Number (ISSN)

  • 0009-7322

Digital Object Identifier (DOI)

  • 10.1161/01.cir.60.2.334


  • eng