Heme oxygenase 1 is required for mammalian iron reutilization.
Journal Article (Journal Article)
The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis. Hmox1-deficient adult mice developed an anemia associated with abnormally low serum iron levels, yet accumulated hepatic and renal iron that contributed to macromolecular oxidative damage, tissue injury, and chronic inflammation. Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.
Full Text
Duke Authors
Cited Authors
- Poss, KD; Tonegawa, S
Published Date
- September 30, 1997
Published In
Volume / Issue
- 94 / 20
Start / End Page
- 10919 - 10924
PubMed ID
- 9380735
Pubmed Central ID
- PMC23531
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.94.20.10919
Language
- eng
Conference Location
- United States