Heart regeneration in zebrafish.
Published
Journal Article
Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection. Regeneration occurs through robust proliferation of cardiomyocytes localized at the leading epicardial edge of the new myocardium. The hearts of zebrafish with mutations in the Mps1 mitotic checkpoint kinase, a critical cell cycle regulator, failed to regenerate and formed scars. Thus, injury-induced cardiomyocyte proliferation in zebrafish can overcome scar formation, allowing cardiac muscle regeneration. These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration.
Full Text
Duke Authors
Cited Authors
- Poss, KD; Wilson, LG; Keating, MT
Published Date
- December 13, 2002
Published In
Volume / Issue
- 298 / 5601
Start / End Page
- 2188 - 2190
PubMed ID
- 12481136
Pubmed Central ID
- 12481136
Electronic International Standard Serial Number (EISSN)
- 1095-9203
Digital Object Identifier (DOI)
- 10.1126/science.1077857
Language
- eng
Conference Location
- United States