Tales of regeneration in zebrafish.


Journal Article (Review)

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. To address this deficiency, we and others have focused on the zebrafish model system. Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins.

Full Text

Duke Authors

Cited Authors

  • Poss, KD; Keating, MT; Nechiporuk, A

Published Date

  • February 2003

Published In

Volume / Issue

  • 226 / 2

Start / End Page

  • 202 - 210

PubMed ID

  • 12557199

Pubmed Central ID

  • 12557199

International Standard Serial Number (ISSN)

  • 1058-8388

Digital Object Identifier (DOI)

  • 10.1002/dvdy.10220


  • eng

Conference Location

  • United States