Duration of apnoea with two different intubating doses of remifentanil.


Journal Article

We have studied the apnoea time after induction with two successful drug intubating regimes, both containing remifentanil. Group 1 (n = 20); propofol 2 mg kg-1 and remifentanil 2 micrograms kg-1 and group 2 (n = 20); propofol 2 mg kg-1, remifentanil 1 microgram kg-1 and lignocaine 1 mg kg-1. Intubation was possible in all 40 patients, and regarded as acceptable in 90% and 85% of patients, respectively. The median time to the return of spontaneous respiration was 487 s in group 1 and 270 s in group 2 (P < 0.05). Median end-tidal CO2 concentration at the time of the first spontaneous respiration was 7.37 kPa in group 1 and 6.3 kPa in group 2 (P < 0.05). Both groups had a decrease in heart rate after induction, but this failed to reach either clinical or statistical significance, and no patient required atropine. Similarly, there was a decrease in arterial pressure after induction in both groups (P < 0.05), but this was not deemed to be clinically significant. Only two patients in each group required ephedrine 6 mg before arterial pressure was restored to within 25% of the base-line. Intubating conditions were similar in both groups, but group 2 provided a significantly shorter apnoea time.

Full Text

Cited Authors

  • Woods, A; Grant, S; Davidson, A

Published Date

  • September 1999

Published In

Volume / Issue

  • 16 / 9

Start / End Page

  • 634 - 637

PubMed ID

  • 10549464

Pubmed Central ID

  • 10549464

Electronic International Standard Serial Number (EISSN)

  • 1365-2346

International Standard Serial Number (ISSN)

  • 0265-0215

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2346.1999.00558.x


  • eng