Acute alcohol decreases gangliosides in mouse brain.

Published

Journal Article

We have reported that single doses of alcohol diminish total sialic acid in rat brain. Recent results indicate that this effect seems to be largely accounted for by alcohol-induced reduction in gangliosides. In these experiments, five replicate groups of mice were injected IP with a single dose of 20% alcohol and saline as control. At 1 hour postinjection, alcohol decreased total brain gangliosides (p less than 0.03) at 1 and 2 g/kg, but not at 3, 4, and 6 g/kg. Free whole-brain sialic acid was increased by 2 g/kg alcohol, which is consistent with the observed decrement in gangliosides at this dose. However, activity of sialidase on the endogenous substrates was not greatly affected by 2 g/kg of alcohol, indicating that ganglioside decrement is probably not attributable to activation of the catabolic enzyme. These results confirm and extend our earlier reports that incriminated gangliosides in the acute action of alcohol. The data also raise the possibility that the effect is due to the "excitatory," rather than the depressive actions of alcohol. Moreover, the action may involve an increased hydrolysis of membrane gangliosides by sialidase.

Full Text

Cited Authors

  • Klemm, WR; Mathew, J; Maring, RG

Published Date

  • May 1988

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 215 - 219

PubMed ID

  • 3415766

Pubmed Central ID

  • 3415766

Electronic International Standard Serial Number (EISSN)

  • 1873-6823

International Standard Serial Number (ISSN)

  • 0741-8329

Digital Object Identifier (DOI)

  • 10.1016/0741-8329(88)90055-9

Language

  • eng