Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass.

Published

Journal Article

BACKGROUND: The PlA2 polymorphism of platelet glycoprotein IIIa has been identified as a prothrombotic risk factor in a number of cardiovascular settings. The aim of this study was to determine whether the PlA2 polymorphism of platelet glycoprotein IIIa and degree of platelet activation were associated with more severe myocardial injury as indicated by troponin I release following cardiopulmonary bypass. METHODS: The PlA2 genotype was determined in 66 patients undergoing elective coronary artery bypass grafting requiring cardiopulmonary bypass. Troponin I concentrations and the percentage of circulating, activated (CD62P+) platelets were measured at predetermined intervals perioperatively. RESULTS: Forty-six patients were Pl(A1,A1), and 20 were Pl(A1,A2) or Pl(A2,A2). Patients with at least one PlA2 allele had significantly greater postoperative troponin I concentrations than PlA1 homozygotes (P = 0.006, analysis of variance). Peak troponin I concentrations also correlated significantly with the increase in circulating, activated platelets (P = 0.02, Spearman rank correlation). CONCLUSIONS: The PlA2 allele of platelet glycoprotein IIIa is associated with higher troponin I concentrations following cardiopulmonary bypass surgery, suggesting that this platelet polymorphism contributes to perioperative myocardial injury.

Full Text

Duke Authors

Cited Authors

  • Rinder, CS; Mathew, JP; Rinder, HM; Greg Howe, J; Fontes, M; Crouch, J; Pfau, S; Patel, P; Smith, BR; Multicenter Study of Perioperative Ischemia Research Group,

Published Date

  • November 2002

Published In

Volume / Issue

  • 97 / 5

Start / End Page

  • 1118 - 1122

PubMed ID

  • 12411794

Pubmed Central ID

  • 12411794

International Standard Serial Number (ISSN)

  • 0003-3022

Language

  • eng

Conference Location

  • United States