Mortality among twins after age 6: fetal origins hypothesis versus twin method.
Journal Article (Journal Article)
ObjectiveTo test the validity of the fetal origins hypothesis and the classic twin method.
DesignFollow up study of pairs of same sex twins in which both twins survived to age 6.
Subjects8495 twin individuals born 1870-1900, followed through to 31 December 1991.
Main outcome measuresMortality calculated on a cohort basis.
ResultsMortality among twins and the general population was not significantly different except among females aged 60-89, in whom mortality among twins was 1.14 times (SE 0.03) higher than in the general population. Mortality among female dizygotic twins was 1.77 times (0.18) higher than among monozygotic twins at age 30-59. Otherwise, mortality for monozygotic and dizygotic twins did not consistently differ after age 6.
ConclusionAccording to the fetal origins hypothesis the risk of adult morbidity and mortality is heightened by retardation in intrauterine growth. Twins, and in particular monozygotic twins, experience growth retardation in utero. The findings in the present study suggest that the fetal origins hypothesis is not true for the retardation in intrauterine growth experienced by twins. Furthermore, the data are inconsistent with the underlying assumption of a recent claim that the classic twin method is invalid for studies of adult diseases. The present study is, however, based on the one third of all pairs of twins in which both twins survived to age 6. The possible impact of this selection can be evaluated in future studies of cohorts of younger twins with lower perinatal and infant mortality.
- Christensen, K; Vaupel, JW; Holm, NV; Yashin, AI
- February 1995
Volume / Issue
- 310 / 6977
Start / End Page
- 432 - 436
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)