Plasmodium berghei sporozoite invasion is blocked in vitro by sporozoite-immobilizing antibodies.


Journal Article

A monoclonal antibody directed against the circumsporozoite protein on the surface of Plasmodium berghei sporozoites inhibited sporozoite motility in vitro. These immobilized sporozoites could adhere to but not invade target cultured cells. Other sporozoite-immobilizing agents also inhibited sporozoite invasion into cultured cells and did not prevent sporozoite adherence. These results indicate that sporozoite invasiveness is associated with sporozoite motility. Thus, the immobilizing effect of this antibody could explain its functional activity against sporozoite invasion in vivo.

Full Text

Cited Authors

  • Stewart, MJ; Nawrot, RJ; Schulman, S; Vanderberg, JP

Published Date

  • March 1, 1986

Published In

Volume / Issue

  • 51 / 3

Start / End Page

  • 859 - 864

PubMed ID

  • 3512436

Pubmed Central ID

  • 3512436

International Standard Serial Number (ISSN)

  • 0019-9567


  • eng

Conference Location

  • United States