An analysis of the duration of fentanyl and its metabolites in urine and saliva.

Published

Journal Article

This study was undertaken to determine if metabolites of fentanyl might be useful in the detection and monitoring of substance abuse. The presence of fentanyl and two of its metabolites in the urine and saliva of seven female patients receiving small doses (110 +/- 56 micrograms) of fentanyl was studied up to 96 h from the time of administration. Fentanyl and its two metabolites (norfentanyl and despropionylfentanyl) were extracted from samples and analyzed by gas chromatography/mass spectrometry. Unchanged fentanyl was detectable in urine in all patients immediately postoperatively and in 3 of 7 patients at 24 h. By 72 h, fentanyl was undetectable. Norfentanyl was present in larger quantities than fentanyl immediately postoperatively and was detected in all patients at 48 h and in 4 of 7 patients at 96 h. Despropionylfentanyl was not detected in any of the urine specimens tested. Neither fentanyl nor its metabolites could be detected consistently at any time in saliva. Saliva testing does not appear to be a viable alternative to urine testing based on this study. Urinary norfentanyl might be considered as the substance of choice when testing for fentanyl abuse.

Full Text

Cited Authors

  • Silverstein, JH; Rieders, MF; McMullin, M; Schulman, S; Zahl, K

Published Date

  • March 1, 1993

Published In

Volume / Issue

  • 76 / 3

Start / End Page

  • 618 - 621

PubMed ID

  • 8452277

Pubmed Central ID

  • 8452277

International Standard Serial Number (ISSN)

  • 0003-2999

Digital Object Identifier (DOI)

  • 10.1213/00000539-199303000-00030

Language

  • eng

Conference Location

  • United States