Assay of erythrocyte components as inhibitors of Plasmodium falciparum merozoite invasion of erythrocytes.


Journal Article

Three red blood cell membrane fractions (Band 3, macromolecules exhibiting I antigenic determinants, and a delipidated glycoprotein fraction) were separated from red blood cell membranes and tested for their ability to inhibit penetration of red blood cells by Plasmodium falciparum merozoites in an in vitro inhibition assay. The delipidated glycoprotein fraction (containing the major sialoglycoproteins and devoid of Band 3) was the only fraction that inhibited merozoite invasion. This fraction showed 73% and 70% inhibition at 1 mg/ml and 500 micrograms/ml, respectively, and slight inhibition below these levels.

Full Text

Cited Authors

  • Schulman, S; Oppenheim, JD; Vanderberg, JP

Published Date

  • July 1, 1983

Published In

Volume / Issue

  • 32 / 4

Start / End Page

  • 666 - 670

PubMed ID

  • 6349394

Pubmed Central ID

  • 6349394

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.1983.32.666


  • eng