Factors and inhibitors of blood coagulation and fibrinolysis in acute nonlymphoblastic leukaemia.


Journal Article

Factors of coagulation and fibrinolysis have been evaluated in 15 patients with untreated acute nonlymphoblastic leukaemia (ANLL). 10 patients had major bleeding (MB) and 6 had laboratory signs of DIC. 5 patients went into complete remission (CR). Antithrombin III (AT III) was decreased in 7 patients, antiplasmin (AP) in 9, fibronectin (FN) in 6 and factor XIII in 4/12. The ratio between factor VIIIR:Ag and factor VIII:C was over 2.0 in 11 patients, and high values were especially seen in patients with MB and patients with DIC. Spontaneous proteolytic activity, measured with S-2288 was increased in 3 patients who all had MB, and none of whom achieved CR. 2 patients with promyelocytic leukaemia (M3) had low fibrinogen and AP, high FDP and normal AT III, speaking for primary fibrinolysis, which in addition to proteolytic enzymes in the blast cells are important contributing factors regarding MB in ANLL.

Full Text

Cited Authors

  • Bratt, G; Blombäck, M; Paul, C; Schulman, S; Törnebohm, E; Lockner, D

Published Date

  • April 1985

Published In

Volume / Issue

  • 34 / 4

Start / End Page

  • 332 - 339

PubMed ID

  • 3858983

Pubmed Central ID

  • 3858983

International Standard Serial Number (ISSN)

  • 0036-553X

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0609.1985.tb00758.x


  • eng

Conference Location

  • Denmark