Skip to main content

Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants.

Publication ,  Journal Article
Guillet, R; Stoll, BJ; Cotten, CM; Gantz, M; McDonald, S; Poole, WK; Phelps, DL ...
Published in: Pediatrics
February 2006

OBJECTIVE: We sought to determine if an association exists between the use of histamine-2 receptor (H2) blockers and the incidence of necrotizing enterocolitis (NEC) in infants of 401 to 1500 g in birth weight. STUDY DESIGN: Data from the National Institute of Child Health and Human Development Neonatal Research Network very low birth weight (401-1500 g) registry from September 1998 to December 2001 were analyzed. The relation between the diagnosis of NEC (Bell stage II or greater) and antecedent H2-blocker treatment was determined by using case-control methodology. Conditional logistic regression was implemented, controlling for gender, site of birth (outborn versus inborn), Apgar score of < 7 at 5 minutes, and postnatal steroids. RESULTS: Of 11072 infants who survived for at least 12 hours, 787 (7.1%) developed NEC (11.5% of infants 401-750 g, 9.1% of infants 751-1000 g, 6.0% of infants 1001-1250 g, and 3.9% of infants 1251-1500 g). Antecedent H2-blocker use was associated with an increased incidence of NEC (P < .0001). CONCLUSIONS: H2-blocker therapy was associated with higher rates of NEC, which is in agreement with a previous randomized trial of acidification of infant feeds that resulted in a decreased incidence of NEC. In combination, these data support the hypothesis that gastric pH level may be a factor in the pathogenesis of NEC.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

February 2006

Volume

117

Issue

2

Start / End Page

e137 / e142

Location

United States

Related Subject Headings

  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Newborn
  • Humans
  • Histamine H2 Antagonists
  • Female
  • Enterocolitis, Necrotizing
  • Case-Control Studies
  • 52 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guillet, R., Stoll, B. J., Cotten, C. M., Gantz, M., McDonald, S., Poole, W. K., … National Institute of Child Health and Human Development Neonatal Research Network, . (2006). Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics, 117(2), e137–e142. https://doi.org/10.1542/peds.2005-1543
Guillet, Ronnie, Barbara J. Stoll, C Michael Cotten, Marie Gantz, Scott McDonald, W Kenneth Poole, Dale L. Phelps, and Dale L. National Institute of Child Health and Human Development Neonatal Research Network. “Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants.Pediatrics 117, no. 2 (February 2006): e137–42. https://doi.org/10.1542/peds.2005-1543.
Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, et al. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb;117(2):e137–42.
Guillet, Ronnie, et al. “Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants.Pediatrics, vol. 117, no. 2, Feb. 2006, pp. e137–42. Pubmed, doi:10.1542/peds.2005-1543.
Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL, National Institute of Child Health and Human Development Neonatal Research Network. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb;117(2):e137–e142.

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

February 2006

Volume

117

Issue

2

Start / End Page

e137 / e142

Location

United States

Related Subject Headings

  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Newborn
  • Humans
  • Histamine H2 Antagonists
  • Female
  • Enterocolitis, Necrotizing
  • Case-Control Studies
  • 52 Psychology