Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).

Journal Article (Journal Article)

The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.

Full Text

Duke Authors

Cited Authors

  • Webster, GD; Sanderson, MR; Skelly, JV; Neidle, S; Swann, PF; Li, BF; Tickle, IJ

Published Date

  • September 1990

Published In

Volume / Issue

  • 87 / 17

Start / End Page

  • 6693 - 6697

PubMed ID

  • 2395870

Pubmed Central ID

  • PMC54603

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.87.17.6693


  • eng

Conference Location

  • United States