Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
Publication
, Journal Article
Webster, GD; Sanderson, MR; Skelly, JV; Neidle, S; Swann, PF; Li, BF; Tickle, IJ
Published in: Proc Natl Acad Sci U S A
September 1990
The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
September 1990
Volume
87
Issue
17
Start / End Page
6693 / 6697
Location
United States
Related Subject Headings
- Oligodeoxyribonucleotides
- Nucleic Acid Conformation
- Molecular Sequence Data
- Models, Molecular
- Hydrogen Bonding
- Guanine
- Crystallization
- Base Sequence
- Base Composition
- Adenine
Citation
APA
Chicago
ICMJE
MLA
NLM
Webster, G. D., Sanderson, M. R., Skelly, J. V., Neidle, S., Swann, P. F., Li, B. F., & Tickle, I. J. (1990). Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG). Proc Natl Acad Sci U S A, 87(17), 6693–6697. https://doi.org/10.1073/pnas.87.17.6693
Webster, G. D., M. R. Sanderson, J. V. Skelly, S. Neidle, P. F. Swann, B. F. Li, and I. J. Tickle. “Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).” Proc Natl Acad Sci U S A 87, no. 17 (September 1990): 6693–97. https://doi.org/10.1073/pnas.87.17.6693.
Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, et al. Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG). Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693–7.
Webster, G. D., et al. “Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).” Proc Natl Acad Sci U S A, vol. 87, no. 17, Sept. 1990, pp. 6693–97. Pubmed, doi:10.1073/pnas.87.17.6693.
Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ. Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG). Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693–6697.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
September 1990
Volume
87
Issue
17
Start / End Page
6693 / 6697
Location
United States
Related Subject Headings
- Oligodeoxyribonucleotides
- Nucleic Acid Conformation
- Molecular Sequence Data
- Models, Molecular
- Hydrogen Bonding
- Guanine
- Crystallization
- Base Sequence
- Base Composition
- Adenine