A two-current model for the dynamics of cardiac membrane.

Published

Journal Article

In this paper we introduce and study a model for electrical activity of cardiac membrane which incorporates only an inward and an outward current. This model is useful for three reasons: (1) Its simplicity, comparable to the FitzHugh-Nagumo model, makes it useful in numerical simulations, especially in two or three spatial dimensions where numerical efficiency is so important. (2) It can be understood analytically without recourse to numerical simulations. This allows us to determine rather completely how the parameters in the model affect its behavior which in turn provides insight into the effects of the many parameters in more realistic models. (3) It naturally gives rise to a one-dimensional map which specifies the action potential duration as a function of the previous diastolic interval. For certain parameter values, this map exhibits a new phenomenon--subcritical alternans--that does not occur for the commonly used exponential map.

Full Text

Duke Authors

Cited Authors

  • Mitchell, CC; Schaeffer, DG

Published Date

  • September 2003

Published In

Volume / Issue

  • 65 / 5

Start / End Page

  • 767 - 793

PubMed ID

  • 12909250

Pubmed Central ID

  • 12909250

Electronic International Standard Serial Number (EISSN)

  • 1522-9602

International Standard Serial Number (ISSN)

  • 0092-8240

Digital Object Identifier (DOI)

  • 10.1016/s0092-8240(03)00041-7

Language

  • eng