Primary tumor of spleen with morphologic features of malignant fibrous histiocytoma. Immunohistochemical evidence for a macrophage origin.

Journal Article (Journal Article)

We report a case of primary splenic malignant fibrous histiocytoma that occurred in a 41-year-old man. Adjacent to the tumor there was a large calcified intrasplenic cyst. Despite splenectomy, postoperative radiation, and systemic chemotherapy, the patient died with metastatic tumor 6 months after diagnosis. Electron microscopic analysis of the tumor demonstrated subpopulations of tumor cells with fibroblastic or histiocytic features. Immunoperoxidase studies of frozen tumor tissue showed positive staining of both spindle and histiocytelike tumor cells with a large panel of monoclonal antibodies against antigens associated with the mononuclear phagocyte system. Expression of these antigens by the tumor supports a mononuclear phagocyte origin.

Full Text

Duke Authors

Cited Authors

  • Sieber, SC; Lopez, V; Rosai, J; Buckley, PJ

Published Date

  • November 1990

Published In

Volume / Issue

  • 14 / 11

Start / End Page

  • 1061 - 1070

PubMed ID

  • 2173430

International Standard Serial Number (ISSN)

  • 0147-5185

Digital Object Identifier (DOI)

  • 10.1097/00000478-199011000-00007


  • eng

Conference Location

  • United States