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Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome.

Publication ,  Journal Article
Tanner, DD; Buckley, PJ; Hong, R; Shearer, WT
Published in: Pediatrics
January 1980

A 4-year-old girl who had received a fetal thymus gland by intraperitoneal transplantation 41 months previously sustained acute, fatal bronchiolitis due to culture-proven cytomegalovirus despite the fact that a specific antibody response to this organism was detected. While the thymic transplantation had increased the number of circulating T lymphocytes and had permitted immune sensitization to delayed-hypersensitivity skin test antigens, there was still an incomplete state of T lymphocyte function. In particular, isolated lymphocytes failed to respond to stimulation with phytohemagglutinin at several concentrations and, more important, the pathologic examination demonstrated a severe anatomic deficiency of lymphoid tissue associated with T lymphocyte function. The unusual infection that caused the death of this child emphasized the necessity of acquiring sufficient T lymphocyte function in immunologic reconstitution attempts.

Duke Scholars

Published In

Pediatrics

ISSN

0031-4005

Publication Date

January 1980

Volume

65

Issue

1

Start / End Page

98 / 102

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Thymus Gland
  • Pediatrics
  • Lymphocyte Activation
  • Immunologic Deficiency Syndromes
  • Immunity, Cellular
  • Humans
  • Female
  • Cytomegalovirus Infections
  • Child, Preschool
 

Citation

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MLA
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Tanner, D. D., Buckley, P. J., Hong, R., & Shearer, W. T. (1980). Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome. Pediatrics, 65(1), 98–102.
Tanner, D. D., P. J. Buckley, R. Hong, and W. T. Shearer. “Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome.Pediatrics 65, no. 1 (January 1980): 98–102.
Tanner DD, Buckley PJ, Hong R, Shearer WT. Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome. Pediatrics. 1980 Jan;65(1):98–102.
Tanner, D. D., et al. “Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome.Pediatrics, vol. 65, no. 1, Jan. 1980, pp. 98–102.
Tanner DD, Buckley PJ, Hong R, Shearer WT. Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome. Pediatrics. 1980 Jan;65(1):98–102.

Published In

Pediatrics

ISSN

0031-4005

Publication Date

January 1980

Volume

65

Issue

1

Start / End Page

98 / 102

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Thymus Gland
  • Pediatrics
  • Lymphocyte Activation
  • Immunologic Deficiency Syndromes
  • Immunity, Cellular
  • Humans
  • Female
  • Cytomegalovirus Infections
  • Child, Preschool