Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome.
Journal Article
A 4-year-old girl who had received a fetal thymus gland by intraperitoneal transplantation 41 months previously sustained acute, fatal bronchiolitis due to culture-proven cytomegalovirus despite the fact that a specific antibody response to this organism was detected. While the thymic transplantation had increased the number of circulating T lymphocytes and had permitted immune sensitization to delayed-hypersensitivity skin test antigens, there was still an incomplete state of T lymphocyte function. In particular, isolated lymphocytes failed to respond to stimulation with phytohemagglutinin at several concentrations and, more important, the pathologic examination demonstrated a severe anatomic deficiency of lymphoid tissue associated with T lymphocyte function. The unusual infection that caused the death of this child emphasized the necessity of acquiring sufficient T lymphocyte function in immunologic reconstitution attempts.
Full Text
Duke Authors
Cited Authors
- Tanner, DD; Buckley, PJ; Hong, R; Shearer, WT
Published Date
- January 1980
Published In
Volume / Issue
- 65 / 1
Start / End Page
- 98 - 102
PubMed ID
- 6243769
Pubmed Central ID
- 6243769
International Standard Serial Number (ISSN)
- 0031-4005
Language
- eng
Conference Location
- United States