Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells.
Journal Article (Journal Article)
Most of the monoclonal antibodies (MoAbs) to T-lymphocyte subsets are, with few exceptions thought to recognize antigens (Ags) unique to T-cells. The authors examined the distribution of cells reacting with MoAbs to the helper/inducer (OKT4, anti-Leu-3a,b) and suppressor/cytotoxic (OKT8, anti-Leu-2a) T-lymphocyte subsets and to "pan T" Ags (anti-Leu-1, anti-Leu-4) in sections from frozen human spleen. In addition to recognizing lymphocytes in the T-zone (periarteriolar lymphoid sheaths), MoAbs to the helper/inducer and suppressor/cytotoxic T-cell subsets reacted distinctly with the red pulp sinusoidal lining cells. MoAbs to "pan T" Ags also reacted with T-zone lymphocytes but did not react with sinusoidal lining cells. MoAbs to the helper/inducer and suppressor/cytotoxic subsets of T-lymphocytes do not appear to identify Ags unique to these cells.
Full Text
Duke Authors
Cited Authors
- Buckley, PJ; Dickson, SA
Published Date
- August 1984
Published In
Volume / Issue
- 82 / 2
Start / End Page
- 167 - 172
PubMed ID
- 6235743
International Standard Serial Number (ISSN)
- 0002-9173
Digital Object Identifier (DOI)
- 10.1093/ajcp/82.2.167
Language
- eng
Conference Location
- England