In vivo production of an RNA-DNA copolymer after infection of Escherichia coli by bacteriophage T4.

Journal Article (Journal Article)

An RNA-DNA copolymer was isolated from Escherichia coli infected with bacteriophage T4. The RNA and DNA are covalently linked, and in the same polynucleotide strand. The DNA of the copolymer hybridizes specifically to the left strand of phage T4 DNA. The copolymer is produced in cells infected with amber mutants of phage T4 deficient in DNA replication and is not inhibited by the addition of chloramphenicol.

Full Text

Duke Authors

Cited Authors

  • Buckley, PJ; Kosturko, LD; Kozinski, AW

Published Date

  • November 1, 1972

Published In

Volume / Issue

  • 69 / 11

Start / End Page

  • 3165 - 3169

PubMed ID

  • 4564205

Pubmed Central ID

  • PMC389727

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.69.11.3165


  • eng

Conference Location

  • United States