Gene transposition as a cause of hybrid sterility in Drosophila.


Journal Article

We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster-D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.

Full Text

Duke Authors

Cited Authors

  • Masly, JP; Jones, CD; Noor, MAF; Locke, J; Orr, HA

Published Date

  • September 2006

Published In

Volume / Issue

  • 313 / 5792

Start / End Page

  • 1448 - 1450

PubMed ID

  • 16960009

Pubmed Central ID

  • 16960009

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1128721


  • eng