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Gene transposition as a cause of hybrid sterility in Drosophila.

Publication ,  Journal Article
Masly, JP; Jones, CD; Noor, MAF; Locke, J; Orr, HA
Published in: Science
September 2006

We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster-D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.

Duke Scholars

Published In

Science

Publication Date

September 2006

Volume

313

Issue

5792

Start / End Page

1448 / 1450

Related Subject Headings

  • Sperm Motility
  • Sodium-Potassium-Exchanging ATPase
  • Reproduction
  • Recombination, Genetic
  • Mutation
  • Male
  • Hybridization, Genetic
  • Genes, Insect
  • General Science & Technology
  • Gene Dosage
 

Citation

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ICMJE
MLA
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Masly, J. P., Jones, C. D., Noor, M. A. F., Locke, J., & Orr, H. A. (2006). Gene transposition as a cause of hybrid sterility in Drosophila. Science, 313(5792), 1448–1450.
Masly, J. P., C. D. Jones, M. A. F. Noor, J. Locke, and H. A. Orr. “Gene transposition as a cause of hybrid sterility in Drosophila.Science 313, no. 5792 (September 2006): 1448–50.
Masly JP, Jones CD, Noor MAF, Locke J, Orr HA. Gene transposition as a cause of hybrid sterility in Drosophila. Science. 2006 Sep;313(5792):1448–50.
Masly, J. P., et al. “Gene transposition as a cause of hybrid sterility in Drosophila.Science, vol. 313, no. 5792, Sept. 2006, pp. 1448–50.
Masly JP, Jones CD, Noor MAF, Locke J, Orr HA. Gene transposition as a cause of hybrid sterility in Drosophila. Science. 2006 Sep;313(5792):1448–1450.

Published In

Science

Publication Date

September 2006

Volume

313

Issue

5792

Start / End Page

1448 / 1450

Related Subject Headings

  • Sperm Motility
  • Sodium-Potassium-Exchanging ATPase
  • Reproduction
  • Recombination, Genetic
  • Mutation
  • Male
  • Hybridization, Genetic
  • Genes, Insect
  • General Science & Technology
  • Gene Dosage