Flying at the head of the pack: Wnt biology in Drosophila.


Journal Article (Review)

The fruitfly, Drosophila melanogaster, has been of central importance in analysing the mechanics of cellular processes. Classic forward genetic screens in the fly have identified many of the genes that define critical cell signaling pathways, for example. Our understanding of the Wnt pathway, in particular, has benefited from the many advantages that the fly offers as a model system. Here, I review the history of these discoveries and highlight the utility of the fly in dissecting the molecular workings of Wnt signal transduction.

Full Text

Duke Authors

Cited Authors

  • Bejsovec, A

Published Date

  • December 2006

Published In

Volume / Issue

  • 25 / 57

Start / End Page

  • 7442 - 7449

PubMed ID

  • 17143288

Pubmed Central ID

  • 17143288

Electronic International Standard Serial Number (EISSN)

  • 1476-5594

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1210051


  • eng