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The effect of nicotinamide on microvascular density and thermal injury in rats.

Publication ,  Journal Article
Smith, YR; Klitzman, B; Ellis, MN; Kull, FC
Published in: J Surg Res
November 1989

The effects of nicotinamide on the microvasculature and wound healing were examined in rats subjected to thermal injury. Rats (250 g) were treated with 50 mg nicotinamide intraperitoneally twice daily for 21 days and then heart and brain biopsies were taken. Skin biopsies were removed from sites in and adjacent to the injury throughout the course of healing. Tissues were stained for alkaline phosphatase and capillary length density was determined by morphometric analysis. Significant increases were observed in the heart, brain, and dermal tissue of treated animals compared to controls. Capillary density in the injured skin was significantly greater when compared to the injured skin of saline-treated controls. The injuries of the rats that were treated systemically with nicotinamide healed significantly faster than saline-treated as determined by planimetric evaluation of the granulation bed and eschar.

Duke Scholars

Published In

J Surg Res

DOI

ISSN

0022-4804

Publication Date

November 1989

Volume

47

Issue

5

Start / End Page

465 / 469

Location

United States

Related Subject Headings

  • Wound Healing
  • Surgery
  • Skin
  • Rats, Inbred Strains
  • Rats
  • Niacinamide
  • Microcirculation
  • Male
  • Coronary Vessels
  • Capillaries
 

Citation

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ICMJE
MLA
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Smith, Y. R., Klitzman, B., Ellis, M. N., & Kull, F. C. (1989). The effect of nicotinamide on microvascular density and thermal injury in rats. J Surg Res, 47(5), 465–469. https://doi.org/10.1016/0022-4804(89)90103-0
Smith, Y. R., B. Klitzman, M. N. Ellis, and F. C. Kull. “The effect of nicotinamide on microvascular density and thermal injury in rats.J Surg Res 47, no. 5 (November 1989): 465–69. https://doi.org/10.1016/0022-4804(89)90103-0.
Smith YR, Klitzman B, Ellis MN, Kull FC. The effect of nicotinamide on microvascular density and thermal injury in rats. J Surg Res. 1989 Nov;47(5):465–9.
Smith, Y. R., et al. “The effect of nicotinamide on microvascular density and thermal injury in rats.J Surg Res, vol. 47, no. 5, Nov. 1989, pp. 465–69. Pubmed, doi:10.1016/0022-4804(89)90103-0.
Smith YR, Klitzman B, Ellis MN, Kull FC. The effect of nicotinamide on microvascular density and thermal injury in rats. J Surg Res. 1989 Nov;47(5):465–469.
Journal cover image

Published In

J Surg Res

DOI

ISSN

0022-4804

Publication Date

November 1989

Volume

47

Issue

5

Start / End Page

465 / 469

Location

United States

Related Subject Headings

  • Wound Healing
  • Surgery
  • Skin
  • Rats, Inbred Strains
  • Rats
  • Niacinamide
  • Microcirculation
  • Male
  • Coronary Vessels
  • Capillaries