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Review of methods used to study oxygen transport at the microcirculatory level.

Publication ,  Journal Article
Dewhirst, MW; Klitzman, B; Braun, RD; Brizel, DM; Haroon, ZA; Secomb, TW
Published in: Int J Cancer
October 20, 2000

The existence of hypoxic regions in tumors has long been recognized as a key factor leading to radiation resistance. More recently, it has been found that low oxygen levels also affect drug resistance, angiogenesis, cytokine production, cell cycle control, apoptosis, and metastatic propensity of tumors. Until now, most approaches to eliminating hypoxia have been empirical. However, improved understanding of the underlying mechanisms may permit the development of more soundly based, effective approaches. As discussed in this review, critical evaluation of the factors governing oxygen transport in tumors requires a thorough understanding of the methods used to study this process. Many experimental methodologies can be used to address these issues. In this review, the emphasis is placed on techniques that measure parameters on the scale of the diffusion distance of oxygen. Studies at the microregional level provide the most detailed physiological information on such processes. Over the past few years, significant progress in technology has allowed us to measure tumor oxygenation, yet spatial and temporal heterogeneities continue to provide significant challenges to obtaining clear knowledge of oxygen transport.

Duke Scholars

Published In

Int J Cancer

ISSN

0020-7136

Publication Date

October 20, 2000

Volume

90

Issue

5

Start / End Page

237 / 255

Location

United States

Related Subject Headings

  • Photometry
  • Oxygen
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Microscopy
  • Microcirculation
  • Hypoxia
  • Humans
  • Cardiovascular System
  • Biosensing Techniques
 

Citation

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Dewhirst, M. W., Klitzman, B., Braun, R. D., Brizel, D. M., Haroon, Z. A., & Secomb, T. W. (2000). Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer, 90(5), 237–255.
Dewhirst, M. W., B. Klitzman, R. D. Braun, D. M. Brizel, Z. A. Haroon, and T. W. Secomb. “Review of methods used to study oxygen transport at the microcirculatory level.Int J Cancer 90, no. 5 (October 20, 2000): 237–55.
Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW. Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer. 2000 Oct 20;90(5):237–55.
Dewhirst, M. W., et al. “Review of methods used to study oxygen transport at the microcirculatory level.Int J Cancer, vol. 90, no. 5, Oct. 2000, pp. 237–55.
Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW. Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer. 2000 Oct 20;90(5):237–255.
Journal cover image

Published In

Int J Cancer

ISSN

0020-7136

Publication Date

October 20, 2000

Volume

90

Issue

5

Start / End Page

237 / 255

Location

United States

Related Subject Headings

  • Photometry
  • Oxygen
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Microscopy
  • Microcirculation
  • Hypoxia
  • Humans
  • Cardiovascular System
  • Biosensing Techniques