Decreased thrombogenicity of vascular prostheses following gas denucleation by hydrostatic pressure.

Journal Article (Journal Article)

The high rate of thrombosis of 1.0-mm polytetrafluoroethylene (PTFE) grafts has limited their use in microvascular surgery. One possible reason for this is the blood-gas interface due to entrapped air in the interstices. The present study examines the effect on patency rates of elimination of this blood-gas interface by high pressurization. Comparing pressurized and nonpressurized grafts in the same animals showed a patency rate of 100 percent at 7 days for treated grafts, while the control (nonpressurized) grafts had all clotted by 1 hour. The implications for microvascular surgery as well as vascular surgery in general are discussed.

Full Text

Duke Authors

Cited Authors

  • Demas, CP; Vann, R; Ritter, E; Sepka, RS; Klitzman, B; Barwick, WJ

Published Date

  • December 1988

Published In

Volume / Issue

  • 82 / 6

Start / End Page

  • 1042 - 1045

PubMed ID

  • 3200940

International Standard Serial Number (ISSN)

  • 0032-1052

Digital Object Identifier (DOI)

  • 10.1097/00006534-198812000-00016


  • eng

Conference Location

  • United States