Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad.

Journal Article

In mammals a single gene on the Y chromosome, Sry, controls testis formation. One of the earliest effects of Sry expression is the induction of somatic cell migration from the mesonephros into the XY gonad. Here we show that mesonephric cells are required for cord formation and male-specific gene expression in XY gonads in a stage-specific manner. Culturing XX gonads with an XY gonad at their surface, as a 'sandwich', resulted in cell migration into the XX tissue. Analysis of sandwich gonads revealed that in the presence of migrating cells, XX gonads organized cord structures and acquired male-specific gene expression patterns. From these results, we conclude that mesonephric cell migration plays a critical role in the formation of testis cords and the differentiation of XY versus XX cell types.

Full Text

Duke Authors

Cited Authors

  • Tilmann, C; Capel, B

Published Date

  • July 1999

Published In

Volume / Issue

  • 126 / 13

Start / End Page

  • 2883 - 2890

PubMed ID

  • 10357932

International Standard Serial Number (ISSN)

  • 0950-1991

Language

  • eng

Conference Location

  • England