Male-to-female sex reversal in mice lacking fibroblast growth factor 9.

Published

Journal Article

Fgfs direct embryogenesis of several organs, including the lung, limb, and anterior pituitary. Here we report male-to-female sex reversal in mice lacking Fibroblast growth factor 9 (Fgf9), demonstrating a novel role for FGF signaling in testicular embryogenesis. Fgf9(-/-) mice also exhibit lung hypoplasia and die at birth. Reproductive system phenotypes range from testicular hypoplasia to complete sex reversal, with most Fgf9(-/-) XY reproductive systems appearing grossly female at birth. Fgf9 appears to act downstream of Sry to stimulate mesenchymal proliferation, mesonephric cell migration, and Sertoli cell differentiation in the embryonic testis. While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species.

Full Text

Duke Authors

Cited Authors

  • Colvin, JS; Green, RP; Schmahl, J; Capel, B; Ornitz, DM

Published Date

  • March 2001

Published In

Volume / Issue

  • 104 / 6

Start / End Page

  • 875 - 889

PubMed ID

  • 11290325

Pubmed Central ID

  • 11290325

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(01)00284-7

Language

  • eng