Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal.

Journal Article (Journal Article)

An approach designed to map and generate mutations in the region of the short arm of the mouse Y chromosome, known to be involved in sex determination and spermatogenesis, is described. This relies on homologous Yp-Sxra pairing and asymmetrical exchange which can occur at meiosis in XY males carrying Sxra on their X chromosome. Such exchange potentially generates deficiencies and duplications of Yp or Sxra. Three fertile XY females were found out of about 450 XY offspring from XSxra/Y x XX crosses. In all three, despite evidence for deletion of Y chromosomal material, the Sry locus was intact. Each deletion involved a repeat sequence, Sx1, located at a distance from Sry. Since expression of Sry was affected these results suggest that long range position effects have disrupted Sry action.

Full Text

Duke Authors

Cited Authors

  • Capel, B; Rasberry, C; Dyson, J; Bishop, CE; Simpson, E; Vivian, N; Lovell-Badge, R; Rastan, S; Cattanach, BM

Published Date

  • November 1993

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 301 - 307

PubMed ID

  • 8275095

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng1193-301


  • eng

Conference Location

  • United States