Skip to main content

Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal.

Publication ,  Journal Article
Capel, B; Rasberry, C; Dyson, J; Bishop, CE; Simpson, E; Vivian, N; Lovell-Badge, R; Rastan, S; Cattanach, BM
Published in: Nat Genet
November 1993

An approach designed to map and generate mutations in the region of the short arm of the mouse Y chromosome, known to be involved in sex determination and spermatogenesis, is described. This relies on homologous Yp-Sxra pairing and asymmetrical exchange which can occur at meiosis in XY males carrying Sxra on their X chromosome. Such exchange potentially generates deficiencies and duplications of Yp or Sxra. Three fertile XY females were found out of about 450 XY offspring from XSxra/Y x XX crosses. In all three, despite evidence for deletion of Y chromosomal material, the Sry locus was intact. Each deletion involved a repeat sequence, Sx1, located at a distance from Sry. Since expression of Sry was affected these results suggest that long range position effects have disrupted Sry action.

Duke Scholars

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

November 1993

Volume

5

Issue

3

Start / End Page

301 / 307

Location

United States

Related Subject Headings

  • Y Chromosome
  • X Chromosome
  • Transcription Factors
  • Sex-Determining Region Y Protein
  • Sex Differentiation
  • Nuclear Proteins
  • Molecular Sequence Data
  • Mice, Inbred Strains
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Capel, B., Rasberry, C., Dyson, J., Bishop, C. E., Simpson, E., Vivian, N., … Cattanach, B. M. (1993). Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet, 5(3), 301–307. https://doi.org/10.1038/ng1193-301
Capel, B., C. Rasberry, J. Dyson, C. E. Bishop, E. Simpson, N. Vivian, R. Lovell-Badge, S. Rastan, and B. M. Cattanach. “Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal.Nat Genet 5, no. 3 (November 1993): 301–7. https://doi.org/10.1038/ng1193-301.
Capel B, Rasberry C, Dyson J, Bishop CE, Simpson E, Vivian N, et al. Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993 Nov;5(3):301–7.
Capel, B., et al. “Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal.Nat Genet, vol. 5, no. 3, Nov. 1993, pp. 301–07. Pubmed, doi:10.1038/ng1193-301.
Capel B, Rasberry C, Dyson J, Bishop CE, Simpson E, Vivian N, Lovell-Badge R, Rastan S, Cattanach BM. Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993 Nov;5(3):301–307.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

November 1993

Volume

5

Issue

3

Start / End Page

301 / 307

Location

United States

Related Subject Headings

  • Y Chromosome
  • X Chromosome
  • Transcription Factors
  • Sex-Determining Region Y Protein
  • Sex Differentiation
  • Nuclear Proteins
  • Molecular Sequence Data
  • Mice, Inbred Strains
  • Mice
  • Male