Expression of a candidate sex-determining gene during mouse testis differentiation.


Journal Article

The development of a eutherian mammal as a male is a consequence of testis formation in the embryo, which is thought to be initiated by a gene on the Y chromosome. In the absence of this gene, ovaries are formed and female characteristics develop. Sex determination therefore hinges on the action of this testis-determining gene, known as Tdy in mice and TDF in humans. In the past, several genes proposed as candidates for Tdy/TDF have subsequently been dismissed on the grounds of inappropriate location or expression. We have recently described a candidate for Tdy, which maps to the minimum sex-determining region of the mouse Y chromosome. To examine further the involvement of this gene, Sry, in testis development, we have studied its expression in detail. Fetal expression of Sry is limited to the period in which testes begin to form. This expression is confined to gonadal tissue and does not require the presence of germ cells. Our observations strongly support a primary role for Sry in mouse sex determination.

Full Text

Duke Authors

Cited Authors

  • Koopman, P; Münsterberg, A; Capel, B; Vivian, N; Lovell-Badge, R

Published Date

  • November 29, 1990

Published In

Volume / Issue

  • 348 / 6300

Start / End Page

  • 450 - 452

PubMed ID

  • 2247150

Pubmed Central ID

  • 2247150

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/348450a0


  • eng

Conference Location

  • England