Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad.

Published

Journal Article

During testis development, the rapid morphological changes initiated by Sry require the coordinate integration of many signaling pathways. Based on the established role of the platelet-derived growth factor (PDGF) family of ligands and receptors in migration, proliferation, and differentiation of cells in various organ systems, we have investigated the role of PDGF in testis organogenesis. Analysis of expression patterns and characterization of the gonad phenotype in Pdgfr-alpha(-/-) embryos identified PDGFR-alpha as a critical mediator of signaling in the early testis at multiple steps of testis development. Pdgfr-alpha(-/-) XY gonads displayed disruptions in the organization of the vasculature and in the partitioning of interstitial and testis cord compartments. Closer examination revealed severe reductions in characteristic XY proliferation, mesonephric cell migration, and fetal Leydig cell differentiation. This work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry in testis organogenesis and Leydig cell differentiation.

Full Text

Duke Authors

Cited Authors

  • Brennan, J; Tilmann, C; Capel, B

Published Date

  • March 15, 2003

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 800 - 810

PubMed ID

  • 12651897

Pubmed Central ID

  • 12651897

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1052503

Language

  • eng

Conference Location

  • United States