Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.

Journal Article

Recently, we demonstrated that loss of Fgf9 results in a block of testis development and a male to female sex-reversed phenotype; however, the function of Fgf9 in sex determination was unknown. We now show that Fgf9 is necessary for two steps of testis development just downstream of the male sex-determining gene, Sry: (1) for the proliferation of a population of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors. The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.

Full Text

Duke Authors

Cited Authors

  • Schmahl, J; Kim, Y; Colvin, JS; Ornitz, DM; Capel, B

Published Date

  • August 2004

Published In

Volume / Issue

  • 131 / 15

Start / End Page

  • 3627 - 3636

PubMed ID

  • 15229180

International Standard Serial Number (ISSN)

  • 0950-1991

Digital Object Identifier (DOI)

  • 10.1242/dev.01239

Language

  • eng

Conference Location

  • England