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Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.

Publication ,  Journal Article
Yao, HHC; Matzuk, MM; Jorgez, CJ; Menke, DB; Page, DC; Swain, A; Capel, B
Published in: Dev Dyn
June 2004

Wnt4(-/-) XX gonads display features normally associated with testis differentiation, suggesting that WNT4 actively represses elements of the male pathway during ovarian development. Here, we show that follistatin (Fst), which encodes a TGFbeta superfamily binding protein, is a downstream component of Wnt4 signaling. Fst inhibits formation of the XY-specific coelomic vessel in XX gonads. In addition, germ cells in the ovarian cortex are almost completely lost in both Wnt4 and Fst null gonads before birth. Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary.

Duke Scholars

Published In

Dev Dyn

DOI

ISSN

1058-8388

Publication Date

June 2004

Volume

230

Issue

2

Start / End Page

210 / 215

Location

United States

Related Subject Headings

  • Wnt4 Protein
  • Wnt Proteins
  • Transforming Growth Factor beta
  • Signal Transduction
  • RNA, Messenger
  • Proto-Oncogene Proteins
  • Ovary
  • Organogenesis
  • Mutation
  • Mice, Knockout
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yao, H. H. C., Matzuk, M. M., Jorgez, C. J., Menke, D. B., Page, D. C., Swain, A., & Capel, B. (2004). Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn, 230(2), 210–215. https://doi.org/10.1002/dvdy.20042
Yao, Humphrey H. C., Martin M. Matzuk, Carolina J. Jorgez, Douglas B. Menke, David C. Page, Amanda Swain, and Blanche Capel. “Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.Dev Dyn 230, no. 2 (June 2004): 210–15. https://doi.org/10.1002/dvdy.20042.
Yao HHC, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, et al. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn. 2004 Jun;230(2):210–5.
Yao, Humphrey H. C., et al. “Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.Dev Dyn, vol. 230, no. 2, June 2004, pp. 210–15. Pubmed, doi:10.1002/dvdy.20042.
Yao HHC, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, Capel B. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn. 2004 Jun;230(2):210–215.
Journal cover image

Published In

Dev Dyn

DOI

ISSN

1058-8388

Publication Date

June 2004

Volume

230

Issue

2

Start / End Page

210 / 215

Location

United States

Related Subject Headings

  • Wnt4 Protein
  • Wnt Proteins
  • Transforming Growth Factor beta
  • Signal Transduction
  • RNA, Messenger
  • Proto-Oncogene Proteins
  • Ovary
  • Organogenesis
  • Mutation
  • Mice, Knockout