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Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.

Publication ,  Journal Article
Kim, Y; Capel, B
Published in: Dev Dyn
September 2006

The embryonic gonads give rise to one of two morphologically and functionally different organs, a testis or an ovary. Sex determination is the embryonic process that determines the developmental fate of the gonad. In mammals, sex determination is regulated by a DNA binding protein encoded on the Y chromosome, Sry, and it's downstream mediator, Sox9, which trigger testis determination in the bipotential gonad. However, evidence suggests that the extracellular signals. Fgf9 and Wnt4, are also required to establish divergent organogenesis of the gonad. In this review, we discuss how these extracellular signals interface with cell-autonomous factors to determine the fate of the mammalian gonad, and we derive a model that could provide a molecular explanation for testis determination in vertebrates where Sry is absent.

Duke Scholars

Published In

Dev Dyn

DOI

ISSN

1058-8388

Publication Date

September 2006

Volume

235

Issue

9

Start / End Page

2292 / 2300

Location

United States

Related Subject Headings

  • Wnt4 Protein
  • Wnt Proteins
  • Testis
  • Signal Transduction
  • Sex-Determining Region Y Protein
  • Sex Determination Processes
  • Proto-Oncogene Proteins
  • Ovary
  • Models, Biological
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, Y., & Capel, B. (2006). Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. Dev Dyn, 235(9), 2292–2300. https://doi.org/10.1002/dvdy.20894
Kim, Yuna, and Blanche Capel. “Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.Dev Dyn 235, no. 9 (September 2006): 2292–2300. https://doi.org/10.1002/dvdy.20894.
Kim, Yuna, and Blanche Capel. “Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.Dev Dyn, vol. 235, no. 9, Sept. 2006, pp. 2292–300. Pubmed, doi:10.1002/dvdy.20894.
Journal cover image

Published In

Dev Dyn

DOI

ISSN

1058-8388

Publication Date

September 2006

Volume

235

Issue

9

Start / End Page

2292 / 2300

Location

United States

Related Subject Headings

  • Wnt4 Protein
  • Wnt Proteins
  • Testis
  • Signal Transduction
  • Sex-Determining Region Y Protein
  • Sex Determination Processes
  • Proto-Oncogene Proteins
  • Ovary
  • Models, Biological
  • Mice