Effects of microgravity on tissue perfusion and the efficacy of astronaut denitrogenation for EVA.


Journal Article

The prevention of astronaut decompression sickness (DCS) during extravehicular activity (EVA) from the Shuttle Orbiter entails basic questions about how the efficacies of pre-EVA denitrogenations are affected by physiological responses and adaptations to microgravity. Many of these questions may be answered, without requiring inflight decompression experiments, when suitable inflight measurements of N2 elimination from spacecrew breathing 100% O2 can be analyzed using an N2 elimination/DCS risk correlation which has been calibrated in ground-based studies. In order to pursue this approach in our laboratory, a potentially flight-applicable, breath-by-breath method for measuring N2 elimination from human subjects breathing 100% O2 for 2-3-h periods has been developed. The present report describes this development with particular emphasis on required methodological accuracy and its achievement in view of certain properties of mass spectrometer performance. A method for the breath-by-breath analysis of errors in measured N2 elimination profiles is also described.

Full Text

Duke Authors

Cited Authors

  • Gerth, WA; Vann, RD; Leatherman, NE; Feezor, MD

Published Date

  • September 1987

Published In

Volume / Issue

  • 58 / 9 Pt 2

Start / End Page

  • A100 - A105

PubMed ID

  • 3675474

Pubmed Central ID

  • 3675474

International Standard Serial Number (ISSN)

  • 0095-6562


  • eng

Conference Location

  • United States