Immunohistochemical localization of prostaglandin endoperoxide synthase in human fetal membranes and decidua.

Journal Article (Journal Article)

Prostaglandins play an important role during the maintenance of pregnancy and the initiation of parturition. Prostaglandin endoperoxide synthase activity has been demonstrated in human fetal membranes and decidua. Using immunohistochemical techniques, we identified in these tissues the cell types that contain prostaglandin endoperoxide synthase. A total of 33 specimens, ranging from 8 wk to 42 wk gestation, were studied. Decidualized stromal cells stained the most intensely and consistently of all cell types. Cytotrophoblast of the chorion and early placental villi and syncytotrophoblast of all gestational ages demonstrated a lighter, more variable staining pattern. Regardless of gestational age, amnion stained in a heterogeneous fashion, with some cells demonstrating an intense staining and other cells having no staining. There were no observable differences in laboring compared to nonlaboring term specimens. In summary, the specific cell types that contain immunoreactive prostaglandin endoperoxide synthase have been identified in fetal membranes and decidua.

Full Text

Duke Authors

Cited Authors

  • Price, TM; Kauma, SW; Curry, TE; Clark, MR

Published Date

  • October 1989

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 701 - 705

PubMed ID

  • 2515894

Pubmed Central ID

  • 2515894

International Standard Serial Number (ISSN)

  • 0006-3363

Digital Object Identifier (DOI)

  • 10.1095/biolreprod41.4.701


  • eng

Conference Location

  • United States