Reactive astrocytes express the embryonic intermediate neurofilament nestin.


Journal Article

Nestin is a neurofilament protein expressed by the immediate precursors to neurons and glia in rats and humans. Nestin immunoreactivity in the rat CNS was studied following kainic acid (KA) hippocampal lesions. Numerous nestin positive cells within the KA lesion were confirmed to be reactive astrocytes by their immunoreactivity for glial fibrillary acidic protein (GFAP). The number of these cells decreased with time after the KA lesion and no astrocyte immunostaining for nestin was observed in control animals. A subset of nestin-positive cells in the ventricular subependymal region appeared to be radial glial cells, extending to cell body layers. Nestin is one of several embryonic markers expressed by reactive astrocytes, suggesting an embryonic reversion induced by the KA lesion, possibly to enhance functional recovery.

Full Text

Duke Authors

Cited Authors

  • Clarke, SR; Shetty, AK; Bradley, JL; Turner, DA

Published Date

  • October 3, 1994

Published In

Volume / Issue

  • 5 / 15

Start / End Page

  • 1885 - 1888

PubMed ID

  • 7841369

Pubmed Central ID

  • 7841369

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199410000-00011


  • eng

Conference Location

  • England