The myoD gene family: nodal point during specification of the muscle cell lineage.

Published

Journal Article (Review)

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

Full Text

Duke Authors

Cited Authors

  • Weintraub, H; Davis, R; Tapscott, S; Thayer, M; Krause, M; Benezra, R; Blackwell, TK; Turner, D; Rupp, R; Hollenberg, S

Published Date

  • February 15, 1991

Published In

Volume / Issue

  • 251 / 4995

Start / End Page

  • 761 - 766

PubMed ID

  • 1846704

Pubmed Central ID

  • 1846704

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1846704

Language

  • eng

Conference Location

  • United States