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Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.

Publication ,  Journal Article
Verma, A; Lewis, D; VanLandingham, KE; Husain, AM; Friedman, AH; Thompson, E; Radtke, RA
Published in: Epilepsy Res
November 2001

Determination of side of seizure onset is critical for a successful outcome following epilepsy surgery. Little is known about the significance of lateralized seizure termination. Sustained seizure activity contralateral to side of seizure onset, following termination of ictal activity ipsilateral to side of onset, may suggest the presence of an independent focus. Such activity, if present, should predict a poor outcome. We studied side of seizure termination in 13 patients undergoing monitoring with bitemporal depth electrodes and correlated this to outcome following anterior temporal lobectomy (ATL). Side of seizure onset was determined for all seizures during that evaluation. Based on side of final cessation of ictal activity, patients were classified as having ipsilateral final termination or simultaneous termination (Group 1; N=6) or contra-lateral or mixed final termination (Group 2; N=7). The Duke outcome classification system was used. At the end of 2 years follow-up, 6/6 patients in Group 1 and 3/7 patients in Group 2 were seizure free. We conclude that lateralized seizure termination during evaluation with depth electrodes may be useful in predicting outcome following ATL. Continued seizure activity contralateral to side of seizure onset (following termination of ictal activity ipsilateral to side of onset) predicts a poor outcome. This may indicate the presence of an independent seizure focus opposite to the side of surgery.

Duke Scholars

Published In

Epilepsy Res

DOI

ISSN

0920-1211

Publication Date

November 2001

Volume

47

Issue

1-2

Start / End Page

9 / 15

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Temporal Lobe
  • Seizures
  • Neurology & Neurosurgery
  • Monitoring, Intraoperative
  • Middle Aged
  • Male
  • Humans
  • Functional Laterality
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Verma, A., Lewis, D., VanLandingham, K. E., Husain, A. M., Friedman, A. H., Thompson, E., & Radtke, R. A. (2001). Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy. Epilepsy Res, 47(1–2), 9–15. https://doi.org/10.1016/s0920-1211(01)00289-3
Verma, A., D. Lewis, K. E. VanLandingham, A. M. Husain, A. H. Friedman, E. Thompson, and R. A. Radtke. “Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.Epilepsy Res 47, no. 1–2 (November 2001): 9–15. https://doi.org/10.1016/s0920-1211(01)00289-3.
Verma A, Lewis D, VanLandingham KE, Husain AM, Friedman AH, Thompson E, et al. Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy. Epilepsy Res. 2001 Nov;47(1–2):9–15.
Verma, A., et al. “Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.Epilepsy Res, vol. 47, no. 1–2, Nov. 2001, pp. 9–15. Pubmed, doi:10.1016/s0920-1211(01)00289-3.
Verma A, Lewis D, VanLandingham KE, Husain AM, Friedman AH, Thompson E, Radtke RA. Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy. Epilepsy Res. 2001 Nov;47(1–2):9–15.
Journal cover image

Published In

Epilepsy Res

DOI

ISSN

0920-1211

Publication Date

November 2001

Volume

47

Issue

1-2

Start / End Page

9 / 15

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Temporal Lobe
  • Seizures
  • Neurology & Neurosurgery
  • Monitoring, Intraoperative
  • Middle Aged
  • Male
  • Humans
  • Functional Laterality
  • Follow-Up Studies