Loss of heterozygosity for 10q loci in human gliomas.

Journal Article (Journal Article)

Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determine the smallest common deletion interval on this chromosome. Seven tumors did not lose heterozygosity for any of the markers. Twenty-three tumors lost an allele for all the informative loci. In 11 tumors heterozygosity was maintained at some loci and lost at other loci, indicating partial deletion of chromosome 10. The common region of deletion in these 11 tumors was located in 10q24-q26 between the markers pHUK-8 and pMCT122.2.

Full Text

Duke Authors

Cited Authors

  • Rasheed, BK; Fuller, GN; Friedman, AH; Bigner, DD; Bigner, SH

Published Date

  • July 1992

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 75 - 82

PubMed ID

  • 1384665

International Standard Serial Number (ISSN)

  • 1045-2257

Digital Object Identifier (DOI)

  • 10.1002/gcc.2870050111


  • eng

Conference Location

  • United States