Ipsilateral subcortical atrophy associated with temporal lobectomy.

Journal Article (Journal Article)

Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also identified altered metabolism in temporal as well as extratemporal regions among these patients. As the temporal cortex and subcortical nuclei of the limbic system are reciprocally connected with striatal projection fields, we examined the putamen nuclei for evidence of associated extratemporal volume asymmetry in patients before and after temporal lobectomy. There was no evidence of preoperative putamen volume asymmetry, but a significant postoperative decrement in ipsilateral putamen volume was observed. The magnitude of postsurgical putamen volume asymmetry was correlated with the duration of time since resection. Progressive degeneration of extratemporal projections of the temporal lobe may occur in association with temporal lobectomy.

Full Text

Duke Authors

Cited Authors

  • Shedlack, KJ; Lee, EK; Radtke, RA; Friedman, AH; Crain, BJ; Boyko, O; Krishnan, KR

Published Date

  • December 1994

Published In

Volume / Issue

  • 54 / 3

Start / End Page

  • 295 - 304

PubMed ID

  • 7792333

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0165-1781(94)90023-x


  • eng

Conference Location

  • Ireland