Phase I study of BCNU and intravenous 6-mercaptopurine in patients with anaplastic gliomas.
Journal Article (Clinical Trial;Journal Article)
On the basis of response rates of up to 50%, BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] is the primary drug used in the chemotherapy of anaplastic gliomas. Preclinical data obtained in several experimental systems show that the cytotoxicity of chloroethylnitrosoureas can be increased by the concomitant use of thiopurines. In this phase I trial, patients with anaplastic gliomas received standard-dose BCNU (200 mg/m2 x 1) in combination with escalating doses of intravenous 6-mercaptopurine (200, 350, 500, and 750 mg/m2 daily x 3), with BCNU being given on day 3 to maximize the effect of the drugs on cellular DNA. No increase in hematologic toxicity was demonstrated as the dose of 6-mercaptopurine was increased. Responses and stabilization of disease were observed in several patients. Due to the safety of and the evidence of activity found for this regimen in the present trial, 750 mg/m2 6-mercaptopurine has been incorporated into subsequent studies.
Full Text
Duke Authors
Cited Authors
- Smith, DC; Vick, NA; Trump, DL; Friedman, HS; Friedman, AH; Purvis, J; Gauspari, A; Schold, SC
Published Date
- 1992
Published In
Volume / Issue
- 30 / 4
Start / End Page
- 272 - 276
PubMed ID
- 1643694
International Standard Serial Number (ISSN)
- 0344-5704
Digital Object Identifier (DOI)
- 10.1007/BF00686294
Language
- eng
Conference Location
- Germany