Phase I study of BCNU and intravenous 6-mercaptopurine in patients with anaplastic gliomas.

Published

Journal Article

On the basis of response rates of up to 50%, BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] is the primary drug used in the chemotherapy of anaplastic gliomas. Preclinical data obtained in several experimental systems show that the cytotoxicity of chloroethylnitrosoureas can be increased by the concomitant use of thiopurines. In this phase I trial, patients with anaplastic gliomas received standard-dose BCNU (200 mg/m2 x 1) in combination with escalating doses of intravenous 6-mercaptopurine (200, 350, 500, and 750 mg/m2 daily x 3), with BCNU being given on day 3 to maximize the effect of the drugs on cellular DNA. No increase in hematologic toxicity was demonstrated as the dose of 6-mercaptopurine was increased. Responses and stabilization of disease were observed in several patients. Due to the safety of and the evidence of activity found for this regimen in the present trial, 750 mg/m2 6-mercaptopurine has been incorporated into subsequent studies.

Full Text

Duke Authors

Cited Authors

  • Smith, DC; Vick, NA; Trump, DL; Friedman, HS; Friedman, AH; Purvis, J; Gauspari, A; Schold, SC

Published Date

  • 1992

Published In

Volume / Issue

  • 30 / 4

Start / End Page

  • 272 - 276

PubMed ID

  • 1643694

Pubmed Central ID

  • 1643694

International Standard Serial Number (ISSN)

  • 0344-5704

Digital Object Identifier (DOI)

  • 10.1007/bf00686294

Language

  • eng

Conference Location

  • Germany