Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.

Journal Article (Journal Article)

The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive proteins are known, none of them in vertebrates. By employing a candidate-gene approach based on genes encoding members of the TRP superfamily of ion channels, we cloned cDNAs encoding the vanilloid receptor-related osmotically activated channel (VR-OAC) from the rat, mouse, human, and chicken. This novel cation-selective channel is gated by exposure to hypotonicity within the physiological range. In the central nervous system, the channel is expressed in neurons of the circumventricular organs, neurosensory cells responsive to systemic osmotic pressure. The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W; Choe, Y; Martí-Renom, MA; Bell, AM; Denis, CS; Sali, A; Hudspeth, AJ; Friedman, JM; Heller, S

Published Date

  • October 27, 2000

Published In

Volume / Issue

  • 103 / 3

Start / End Page

  • 525 - 535

PubMed ID

  • 11081638

Pubmed Central ID

  • PMC2211528

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)00143-4


  • eng

Conference Location

  • United States