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Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.

Publication ,  Journal Article
Cohen, P; Miyazaki, M; Socci, ND; Hagge-Greenberg, A; Liedtke, W; Soukas, AA; Sharma, R; Hudgins, LC; Ntambi, JM; Friedman, JM
Published in: Science
July 12, 2002

Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids. Mice lacking SCD-1 were lean and hypermetabolic. ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure. ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

July 12, 2002

Volume

297

Issue

5579

Start / End Page

240 / 243

Location

United States

Related Subject Headings

  • Weight Loss
  • Vacuoles
  • Stearoyl-CoA Desaturase
  • RNA, Messenger
  • Oxygen Consumption
  • Oligonucleotide Array Sequence Analysis
  • Mutation
  • Microsomes, Liver
  • Mice, Obese
  • Mice
 

Citation

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Cohen, P., Miyazaki, M., Socci, N. D., Hagge-Greenberg, A., Liedtke, W., Soukas, A. A., … Friedman, J. M. (2002). Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science, 297(5579), 240–243. https://doi.org/10.1126/science.1071527
Cohen, Paul, Makoto Miyazaki, Nicholas D. Socci, Aaron Hagge-Greenberg, Wolfgang Liedtke, Alexander A. Soukas, Ratnendra Sharma, Lisa C. Hudgins, James M. Ntambi, and Jeffrey M. Friedman. “Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.Science 297, no. 5579 (July 12, 2002): 240–43. https://doi.org/10.1126/science.1071527.
Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002 Jul 12;297(5579):240–3.
Cohen, Paul, et al. “Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.Science, vol. 297, no. 5579, July 2002, pp. 240–43. Pubmed, doi:10.1126/science.1071527.
Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002 Jul 12;297(5579):240–243.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

July 12, 2002

Volume

297

Issue

5579

Start / End Page

240 / 243

Location

United States

Related Subject Headings

  • Weight Loss
  • Vacuoles
  • Stearoyl-CoA Desaturase
  • RNA, Messenger
  • Oxygen Consumption
  • Oligonucleotide Array Sequence Analysis
  • Mutation
  • Microsomes, Liver
  • Mice, Obese
  • Mice