Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
Journal Article (Journal Article)
Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids. Mice lacking SCD-1 were lean and hypermetabolic. ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure. ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions.
Full Text
Duke Authors
Cited Authors
- Cohen, P; Miyazaki, M; Socci, ND; Hagge-Greenberg, A; Liedtke, W; Soukas, AA; Sharma, R; Hudgins, LC; Ntambi, JM; Friedman, JM
Published Date
- July 12, 2002
Published In
Volume / Issue
- 297 / 5579
Start / End Page
- 240 - 243
PubMed ID
- 12114623
Electronic International Standard Serial Number (EISSN)
- 1095-9203
Digital Object Identifier (DOI)
- 10.1126/science.1071527
Language
- eng
Conference Location
- United States