Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.

Journal Article (Journal Article)

We studied the prevalence of antibody to rotavirus in 386 serum samples obtained from different age-groups of infants in Bochum, West Germany. Cord sera mirrored the IgG titer and serotype specificity of the corresponding maternal sera. IgG antibody prevalence decreased with age, reached a minimum between four and 12 months, and increased thereafter. IgM antibodies appeared first in the eight- to 12-month age-group, and IgM prevalence remained high thereafter. The serum level of IgA was low in all age-groups. Significant prevalence increases with increasing age were observed for neutralizing antibodies to rotavirus serotypes 1 and 3. Antibodies to serotype 4 had not reached adult level at 2.5 y of age. Prevalence of antibodies to serotype 2 was low in all age-groups. The percentage of monospecific sera neutralizing only one serotype was high in young infants eight to 12 months of age and decreased significantly with increasing age.

Full Text

Duke Authors

Cited Authors

  • Brüssow, H; Werchau, H; Liedtke, W; Lerner, L; Mietens, C; Sidoti, J; Sotek, J

Published Date

  • May 1988

Published In

Volume / Issue

  • 157 / 5

Start / End Page

  • 1014 - 1022

PubMed ID

  • 2834458

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/157.5.1014


  • eng

Conference Location

  • United States