Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.

Journal Article

We studied rotavirus-specific antibodies in paired sera from 71 hospitalized infants with acute rotavirus gastroenteritis. Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay, 46% of the 71 infants studied showed specific IgM in convalescent sera. Titers of specific IgG and IgA increased in 7% and 2% of the infants, respectively. The presence of specific IgM correlated positively with age and severity of clinical symptoms. With a neutralization test, 59% of the infants showed a seroconversion: 20% to a single serotype (7% to serotype 1, 7% to serotype 3, and 6% to serotype 4), 21% seroconverted to two serotypes (nearly exclusively to serotypes 1 and 3), and 18% seroconverted to three serotypes (exclusively to serotypes 1, 3, and 4). No infant seroconverted to serotype 2 or to the heterologous (bovine) serotype 6.

Full Text

Duke Authors

Cited Authors

  • Brüssow, H; Werchau, H; Lerner, L; Mietens, C; Liedtke, W; Sidoti, J; Sotek, J

Published Date

  • September 1988

Published In

Volume / Issue

  • 158 / 3

Start / End Page

  • 588 - 595

PubMed ID

  • 2842406

International Standard Serial Number (ISSN)

  • 0022-1899

Language

  • eng

Conference Location

  • United States