Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.

Journal Article (Journal Article)

We report the clinical history, neuroradiology, and autopsy findings in a patient with very late onset, at age 57, of adrenoleukodystrophy (ALD) presenting with dementia, hemianopia, and gait apraxia. Open brain biopsy, elevated plasma very-long-chain fatty acids, and autopsy confirmed the diagnosis of ALD. Demyelinative lesions were most extensive at the site of a recent cerebral contusion. CNS trauma may have precipitated or accelerated demyelination in this patient carrying the ALD gene.

Full Text

Duke Authors

Cited Authors

  • Weller, M; Liedtke, W; Petersen, D; Opitz, H; Poremba, M

Published Date

  • February 1, 1992

Published In

Volume / Issue

  • 42 / 2

Start / End Page

  • 367 - 370

PubMed ID

  • 1736167

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.42.2.367

Language

  • eng

Conference Location

  • United States