Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.
Journal Article (Journal Article)
We report the clinical history, neuroradiology, and autopsy findings in a patient with very late onset, at age 57, of adrenoleukodystrophy (ALD) presenting with dementia, hemianopia, and gait apraxia. Open brain biopsy, elevated plasma very-long-chain fatty acids, and autopsy confirmed the diagnosis of ALD. Demyelinative lesions were most extensive at the site of a recent cerebral contusion. CNS trauma may have precipitated or accelerated demyelination in this patient carrying the ALD gene.
Full Text
Duke Authors
Cited Authors
- Weller, M; Liedtke, W; Petersen, D; Opitz, H; Poremba, M
Published Date
- February 1, 1992
Published In
Volume / Issue
- 42 / 2
Start / End Page
- 367 - 370
PubMed ID
- 1736167
International Standard Serial Number (ISSN)
- 0028-3878
Digital Object Identifier (DOI)
- 10.1212/wnl.42.2.367
Language
- eng
Conference Location
- United States